Users may select one of the available resampling methods adaptive (best quality), is selected by default. The existing resampling modes, bilinear and bicubic, have seen quality updates as well according to the developer. Paint.Net 5.0's image resize tool, located under Image > Resize or by pressing Ctrl-R, supports two new resampling modes, adaptive and lanczos. It smoothes the brush stroke using a 'centripetal Catmull-rom spline'.

The feature supports path smoothing, which is enabled by default. It enables Paint.Net users to draw 'beautiful, natural-looking brush strokes'. The new release introduces support for pressure sensitivity this requires a Windows Ink compatible input device. Performance is just one area of improvements. The first enables them to toggle hardware acceleration for the user interface and the canvas, the second to select the rendering device, if multiple graphics processing units are available. Paint.Net 5.0 users find two graphics controls in the Settings. An added benefit of the change is that the 'quality of rendering and the accuracy of colors' is greatly improved. Besides user interface accelerations, most 'adjustments and effects' use the GPU now in the new release. In Paint.Net 5.0, core user interface parts, including the history and layers windows, the ruler, the image list and the Curves and Levels adjustment user interfaces make use of GPU acceleration.

The new version expands GPU acceleration work that started in Paint.Net 4.0. One of the main improvements is performance in the new version of Paint.Net. Paint.Net 5.0 is a major new release that 'has many major performance improvements, new features including pressure sensitivity for pens and drawing tablets, and a brand new effect plugin system with GPU rendering support' according to the author of Paint.Net.

Older versions of Windows are no longer supported, and users who still run these devices may keep on running 4.x instead. The new version runs only on 64-bit versions of Windows 10 and 11. Paint.Net 5.0 is a new major release that makes changes to the program's system requirements.

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